SOYGAN

SOYGAN

SOYGAN

Dosage Forms: Capsule

Containing  500mg of the powder and extract of soybean (Glycine soja L.)

  • SOYGAN
  • SOYGAN

Indications

Osteoporosis prevention, alleviation of menopausal symptoms (hot flush, bone mineral loss), prevention of prostate & breast cancer, cardiovascular diseases and GI disorders

Pharmacology

Isoflavones are known as phytoestrogens (natural estrogen) and have similar but lower effects including hormonal and nonhormonal actions because of broadly similarity to the main female hormone, estradiol. Isoflavones act at the level of hypothalamus and pituitary to alter gonadotropin secretion and serves as both agonist and antagonist and it is dose-dependent effect.

Phytoestrogens show a competitive binding for mammary tissue estrogen receptors, raising the possibility of stimulation of estrogen- dependent neoplasm. In large doses, the phytoestrogens inhibit breast cancer development and suppress tumor growth.

Genistein’s protective effect against cancer may be due to its inhibition of growth-promoting steroid hormone metabolism by inhibiting 5α- reductase and 17β- hydroxyl steroid dehydrogenase. Genistein is a potent inhibitor of protein tyrosin kinase (PTK), which plays an important role in cell growth and smooth muscle contraction. Because of this inhibitory effect, genistein can cause an apoptosis of cancer cells and reduce the proliferation of human malignant cells.

Direction

Take one capsule, 3 times a day, 1-2 hour after the mealtime

Drug Interaction

Concurrent use of soy and minerals such as Fe, Ca and Zn, reduce minerals adsorption, thus administration times should be separated by two hours or more.

Concurrent use of soy and Levothyroxine decrease effectiveness of Levothyroxine, thus administration times should be separate by two hours or more and thyroid function tests should be monitor in patients who elect to use soy with levothyroxine.

Concurrent use of soy and medicines such as raloxifene, tamoxifen or warfarin decrease effectiveness warfarin. Avoid concomitant use of soy.

Side effects

No health hazards are known in conjunction with the proper administration of designated therapeutic dosages. However, there is the possibility of allergic reactions in sensitive individuals.

Constituents

Soybean extract and powder

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